Both sides will be without their England internationals for the match as they have already joined up with the national team for the upcoming Six Nations.
Harlequins will be without eight players including star fly-half Marcus Smith, while Saints will be denied the services of seven key individuals.
Former club captain Stephan Lewies will still lead out a Quins team that includes Jack Walker, Joe Launchbury, Will Evans, James Chisholm and Danny Care.
“It’s the Premiership champions at home, we had a narrow loss to them away. Both sides will have a different look to them than they did in their European fixtures, but both sides are capable of some unbelievable rugby,” Wilson added.
“Being at The Stoop’s important to us because it’s in front of our fans, we’ve got an unbelievably good group of fans – very supportive atmosphere at The Stoop, we felt that on Saturday night, it made a difference and I’m hoping on Friday night they’ll do the same.”
